Author

Wei Dai

Cornell University

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Biology Disciplines

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Genetic & Genomic Medicine· 1 Neuroscience· 1 Plant Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Adithya Sagar· 1 shared Chao Ma· 1 shared Chen ChengiD· 1 shared Chunyu Deng· 1 shared Dingping Jiang· 1 shared Edward Cedrick Fernandez· 1 shared Fei QiuiD· 1 shared Gaoya Tu· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperSystems Biology

Adithya Sagar

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4 papers

Recent·Most cited

Spatial Coordination between Leaf Gradient and Temperature Response in Barley

Edward Cedrick Fernandez, Gaoya Tu, Wei Dai, Shengming Yang, Zhaohui Liu, Marcin Grzybowski, Zhikai Liang

This study identifies spatially distinct heat responses in barley leaves using chlorophyll fluorescence imaging and transcriptomic profiling, revealing region-specific gene expression patterns and potential targets for improving heat resilience.

The Plant Journal · Apr 1, 2026Peer-reviewedPlant Biology

Spatial mapping of α-synuclein seeding activity and pathology using immunofluorescence-integrated quiescent seed amplification

Hengxu Mao, Yaoyun Kuang, Zerui Wang, Hao Lin, Wei Dai, Tingting Gan, Zhengxiao He, Wen-quan Zou, Chao Ma, Yue Huang, Jinkun Huang, Pingyi Xu

This paper introduces IF-QSAA, a method that maps alpha-synuclein seeding activity and pathology in tissue, revealing white-matter enrichment and resolving hemispheric asymmetry in Parkinson's disease.

bioRxiv · Mar 26, 2025 · PreprintNeuroscience

Integration of human organoids single-cell transcriptomic profiles and human genetics repurposes critical cell type-specific drug targets for severe COVID-19

Yunlong Ma, Yijun Zhou, Dingping Jiang, Wei Dai, Jinɡjinɡ Li, Chunyu Deng, Chen Cheng, Gongwei Zheng, Yaru Zhang, Fei Qiu, Haojun Sun, Shilai Xing, Haijun Han, Jia Qu, Nan Wu, , Jianzhong Su

The paper integrates human organoid scRNA-seq data with GWAS and gene-drug interaction data to identify cell type-specific drug targets for severe COVID-19.

Cell Proliferation · Oct 8, 2023Peer-reviewedGenetic & Genomic Medicine

Reduced order modeling and analysis of the human complement system

Adithya Sagar, Wei Dai, Mason Minot, Rachel LeCover, Jeffrey D. Varner

The paper develops a reduced order mathematical model of the human complement system that is predictive and computationally efficient, showing that multiple therapeutic targets are needed to disrupt complement activation.

PLoS ONE · Nov 20, 2017Peer-reviewedSystems Biology