Combining transformer and 3DCNN models to achieve co-design of structures and sequences of antibodies in a diffusional manner
Yue Hu, Feng Tao, Jiajie Xu, Wen-Jun Lan, Jing Zhang, Wei Lan
The paper introduces AlphaPanda, an algorithm combining transformer, 3DCNN, and diffusion models for antibody sequence and structure design, achieving high-quality results with reduced training data.
Journal of Pharmaceutical Analysis · Mar 15, 2025Peer-reviewedBioinformatics