ILF2 blockade suppresses helicase-mediated R-loop resolution to induce lethality in homologous recombination-deficient cancers
Yi Chieh Lim, Soak Kuan Lai, Ru Yang, Yong Kang Chua, Rémi Patouret, Vaishnervi Manoj, C Soh, Benjamin Lebeau, Ning Cham, Wei Meng, Sze Keong Tey, Szu Ling Yeap, Songjing Zhang, Jessie Yong Xing Woon, Zahin Mohd Ali, , HY Li
This study identifies NYH0002 as a compound that blocks ILF2, leading to DNA breaks and lethality in cancers with specific genetic profiles.
bioRxiv · May 21, 2025 · PreprintCancer Biology