Author
Memorial Sloan Kettering Cancer Center
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
Teng Han, Zhen Sun, Matthew Lange…·Charles L. Sawyers
Loss of extracellular matrix-integrin signaling switches off YAP/TEAD and lets prostate adenocarcinoma organoids turn neuroendocrine; LATS inhibition reverses it, and combined YAP, NOTCH and AR inhibition fully reprograms them.
Young Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz…·Charles L. Sawyers
This study identifies an IL-1β/IL-6 signaling circuit in the tumor microenvironment that drives prostate cancer progression from pre-invasive to invasive stages.
Emily A. Costa, Barbara Vaz de Mello, Corrin A. Wohlhieter…·Charles M. Rudin
The paper identifies SMARCA4/STK11/KEAP1 triple mutant lung adenocarcinoma as a poor prognosis subset and links it to TGF-β pathway activation.
Samir Zaidi, Maren Büttner, Weiran Feng…·Charles L. Sawyers
The paper integrates single-cell multiomics and CRISPR screening in prostate cancer organoids to reveal lineage-specific dependencies and heterogeneity effects on gene essentiality.
Dan Li, Naitao Wang, Wangxin Guo…·Yu Chen
This study shows that luminal prostatic epithelial cells depend on AR signaling for survival and differentiation, and their loss triggers compensatory pathways and lineage plasticity.
Magdalini Panagiotakopoulou, Ashley N. Sullivan, Kimon V. Argyropoulos…·Daniel A. Heller
The paper identifies galectin-3 as a target for nanotherapeutic delivery of ruxolitinib to reduce GVHD-related kidney injury and systemic inflammation.
Rodrigo Romero, Tinyi Chu, Tania J González-Robles…·Charles L. Sawyers
This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.