Author

William Bryant

University of Nebraska–Lincoln

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Systems Biology· 1

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:large language model· 1 Assay:metabolomics· 1

Frequent Co-Authors

Ahmed Abdeen HamediD· 1 shared Bhanwar Lal PuniyaiD· 1 shared Josh LoeckeriD· 1 shared Narayana Pujara· 1 shared Prakash PackrisamyiD· 1 shared Tomáš HelikariD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperSystems Biology

Ahmed Abdeen HamedORCID

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Recent·Most cited

MechAInistic: An LLM-guided Multi-Agent System for Reasoning over Genome-Scale Constraint-Based Metabolic Models

Josh Loecker, Narayana Pujara, William Bryant, Bhanwar Lal Puniya, Prakash Packrisamy, Ahmed Abdeen Hamed, Tomáš Helikar

MechAInistic uses a multi-agent system guided by LLMs to generate auditable hypotheses from genome-scale metabolic models, identifying potential drug targets and metabolic rewiring in disease states.

bioRxiv · Jul 22, 2026 · PreprintSystems Biology