Hyperacute Response Proteins (HARPs) synthesized on γ-tubulin-FTO-MARK4 translation microdomains upon exposure to stress, regulate stressresponse in cancer.
Bruno Saleme, Saymon Tejay, Paul Dembele Kleouforo, Rabih Abou Farraj, Yongneng Zhang, Yongsheng Liu, Aristeidis E. Boukouris, Sotirios D. Zervopoulos, Alois Haromy, Yuanyuan Zhao, Shelly Braun, William Saleme, Xuejun Sun, Richard P. Fahlman, Mark Glover, , Evangelos D. Michelakis
The paper identifies stress-responsive proteins (HARPs) synthesized on γ-tubulin-FTO-MARK4 translation microdomains in cancer cells, showing their role in stress resistance and potential as therapeutic targets.
bioRxiv · Jan 20, 2025 · PreprintCancer Biology