Author

William Sineath

Pacific Northwest National Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Organism:E. coli· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Jordan C. RozumiD· 3 shared Pavlo BohutskyiiD· 3 shared Angad P. MehtaiD· 2 shared Connah JohnsoniD· 2 shared D. H. Kim· 2 shared James E. EvansiD· 2 shared Marci Garcia· 2 shared Margaret S. CheungiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Jordan C. RozumORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell State Transitions Drive Transcriptome-Proteome Alignment in a Minimal Photoautotroph

Jordan C. Rozum, Xiaolu Li, Young‐Mo Kim, Zachary Johnson, William Sineath, Marci Garcia, Natalie Sadler, Pavlo Bohutskyi, Margaret Cheung, Wei-Jun Qian, Song Feng

The paper investigates how cell state transitions in Prochlorococcus marinus MED4 affect transcriptome-proteome alignment through regulatory mechanisms involving RpaB and HimA.

bioRxiv · Oct 21, 2026 · PreprintSystems Biology

Spatiotemporal 4D Whole-cell Modeling of a Minimal Autotroph Reveals Central Carbon Metabolism Regulated Locally by Protein Megacomplexes via Post-translational Modifications under Light Disturbance

Connah Johnson, Aaron Chan, Jordan C. Rozum, August George, Amar D. Parvate, Pavlo Bohutskyi, D. H. Kim, Song Feng, Zachary Johnson, Natalie Sadler, Marci Garcia, Xiaolu Li, Jesse B. Trejo, Ruonan Wu, William Sineath, , Margaret S. Cheung

The paper develops a 4D whole-cell model of Prochlorococcus marinus MED4 to show how spatial organization and redox PTMs regulate carbon fixation under light disturbance.

Biophysical Journal · Aug 26, 2026Peer-reviewedSystems Biology

Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophage

Jordan C. Rozum, William Sineath, Pavlo Bohutskyi, Jordan Quenneville, D. H. Kim, Connah Johnson, Angad P. Mehta, James E. Evans, David D. Pollock, Weijun Qian, Margaret S. Cheung, Ruonan Wu, Song Feng

The paper integrates AMGs and phage assembly into a genome-scale metabolic model to predict their impact on host metabolism and phage production, revealing synergistic and antagonistic effects.

Science Advances · Apr 1, 2026Peer-reviewedSystems Biology