The Parkinson's disease-associated A53E mutation decreases alpha-synuclein aggregation and phosphorylation in vivo
Willow L. Irving, Sadie Meredith-Andrews, Kyle T. Nguyen, K. Lily Schainker, Nicole L. Brockway, Vivek K. Unni, Tamily A. Weissman
This study shows that the A53E mutation in alpha-synuclein reduces aggregation and phosphorylation in vivo, leading to delayed progression of Parkinson's disease.
bioRxiv · Oct 30, 2026 · PreprintNeuroscience