Overlapping MHC class I/II Epitopes Program cDC1-like Differentiation of Monocyte-Derived Dendritic Cells via mTORC1 Signaling Inhibition
Sharon Bright Amanya, Arnav Murthy, Nalini Bisht, Zaniqua N. Bullock, Keenan Ernste, Jonathan Vazquez‐Perez, W. Liu, Akshar J. Trivedi, Damilola Oyewole-Said, A Paul, Leilani Umokoro, Viktor Akhanov, Melanie A. Samuel, Zhongcheng Shi, Michael Nguyen, , WK Decker
The paper shows that overlapping MHC class I/II epitopes promote cDC1-like differentiation of moDC through mTORC1 inhibition, enhancing type 1 immunity.
bioRxiv · Apr 8, 2026 · PreprintImmunology