Coordinate Up-regulation of Both TK1 and TS Expression in Cycling Cells: Mechanistic Basis and Implications for Dual-Targeted Cancer Therapy
Wanxing Wang, Jiawei Zhang, Guangyou Duan, Yiyao Zhang, Guofeng Xu, Zhi Cheng, Shunmei Chen, Xue Yao, X Li, Gao Shan
The paper identifies coordinate up-regulation of TK1 and TS in cycling cells and shows it is essential for dTTP supply, supporting dual-targeted cancer therapy.
bioRxiv · Jan 2, 2026 · PreprintCancer Biology