HSF1 inhibition potentiates the antifungal activity and proteome instability induced by the fungal Hsp110 inhibitor 2H
Cancan Sun, Balaji Nagarajan, Arjun Rijal, Charles E. Lyons, Abu Hamza, Wei Wang, Xianjun Fang, Yana Cen, Qinglian Liu
This study shows that combining HSF1 inhibition with Hsp110 inhibitor 2H enhances antifungal activity by increasing proteome instability in fungal pathogens.
bioRxiv · Oct 13, 2026 · PreprintMicrobiology