Author

Xiao Yu

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Deborah Tan HungiD· 2 shared Thulasi WarrieriD· 2 shared Tomohiko Kawate· 2 shared Aaron J. GolasiD· 1 shared Andras BoeszoermenyiiD· 1 shared Benjamin PetersiD· 1 shared Bo LiiD· 1 shared Bradley E. PoulseniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

Deborah Tan HungORCID

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3 papers

Recent·Most cited

Extracellular vesicles drive cross-genus mycovirus transmission and suppress two fungal diseases

Jianing Wu, Jialing Xu, Shutong Yang, Yang Lin, Huang Huang, Jiǎtāo Xiè, Jiāsēn Chéng, Tao Chen, Bo Li, Xiao Yu, Xueliang Lv, Yànpíng Fù, Xueqiong Xiao, Qing Cai, Dàohóng Jiāng

This paper identifies fungal extracellular vesicles as mediators of cross-genus mycovirus transmission and shows they reduce fungal disease severity.

bioRxiv · Aug 3, 2026 · PreprintMicrobiology

Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens

Megan W. Tse, Meilin Zhu, Benjamin Peters, Efrat Hamami, Julie Chen, Kathleen P. Davis, Samuel Nitz, Juliane Weller, Thulasi Warrier, Diana K. Hunt, Yoelkys Morales, Tomohiko Kawate, Jeffrey L. Gaulin, Jon H. Come, Juan Hernandez-Bird, , Paul C. Blainey

This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.

Proceedings of the National Academy of Sciences · Mar 24, 2025Peer-reviewedMicrobiology

Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS

Bradley E. Poulsen, Thulasi Warrier, Sulyman Barkho, Josephine Bagnall, Keith P. Romano, T. L. White, Xiao Yu, Tomohiko Kawate, Phuong H. Nguyen, Kyra Raines, Kristina M. Ferrara, Aaron J. Golas, Michael G. FitzGerald, Andras Boeszoermenyi, Virendar K. Kaushik, , Deborah Tan Hung

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

Cell chemical biology · Dec 27, 2024Peer-reviewedMicrobiology