Author

Xiaobo zhou

The University of Texas Health Science Center at Houston

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Biology Disciplines

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Bioinformatics· 5 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:imaging· 2 Approach:machine learning (classical)· 2

Frequent Co-Authors

Haotian DangiD· 2 shared Hongyu Wang· 2 shared Lei YouiD· 2 shared Yankai YuiD· 2 shared Akash J. PateliD· 1 shared Akdes Serin HarmancıiD· 1 shared Arif O. HarmanciiD· 1 shared Benjamin DeneeniD· 1 shared

Activity by Year

2021-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBioengineering

Haotian DangORCID

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Author profile →

6 papers

Recent·Most cited

An FEV-Associated Metastasis-Initiating-Like State Linked to Tumor Cell Plasticity and Immune Niche Remodeling in Prostate Cancer

Sijia Wu, Jiangpeng Wei, Xiaorui Shi, Xin Liu, Xiaobo zhou, Liyu Huang

The paper identifies a metastasis-initiating-like state in prostate cancer linked to FEV, tumor plasticity, and immune niche remodeling through integrated multi-omics analysis.

bioRxiv · Sep 29, 2026 · PreprintBioinformatics

AC-Diff: Anatomy-Contrast Disentangled Diffusion for Multi-Vendor Liver MRI Harmonization

Hansen Feng, Haotian Dang, Lei You, Hongyu Wang, Xiaobo zhou

AC-Diff improves liver MRI harmonization by separating anatomy from contrast, achieving better segmentation results.

bioRxiv · Sep 29, 2026 · PreprintBioengineering

Systematic Benchmarking of AI-Based Molecular Generation Models for Structure-Based Drug Design

Himansu Kumar, Zhengxiao Yang, Yankai Yu, Jianguo Wen, Pora Kim, Xiaobo Zhou

This study benchmarks 12 AI-based molecular generation models for drug design across 176 protein-ligand systems, finding no single method optimizes all criteria and proposing a hybrid approach.

bioRxiv · Aug 20, 2026 · PreprintBioinformatics

PFM: perturbed flow matching for structure-based drug design

Yankai Yu, Guikun Xu, Zhuyang Xie, Yi Yang, Yi Jiang, Xiaobo Zhou, Li K

PFM generates 3D molecules that bind to protein targets with competitive structures and SOTA binding affinities, while significantly accelerating the generation process.

bioRxiv · Jul 17, 2026 · PreprintBioinformatics

Anatomy-Guided 3D Graph Networks for Couinaud Segmentation in Tumor Affected Livers

Lei You, Haotian Dang, Hongyu Wang, Eduardo da Matta, Xiaobo zhou

This paper introduces a two-stage framework combining 3D UNet and 3D GCN for accurate Couinaud segmentation in tumor-affected livers, achieving a mean Dice score of 0.828 on blind testing.

bioRxiv · Jun 29, 2026 · PreprintBioinformatics

scRegulocity: Detection of local RNA velocity patterns in embeddings of single cell RNA-Seq data

Akdes Serin Harmancı, Arif O. Harmanci, Xiaobo Zhou, Benjamin Deneen, Ganesh Rao, Tiemo Jürgen Klisch, Akash J. Patel

scRegulocity detects local RNA velocity patterns in single-cell RNA-seq embeddings to identify regulatory changes and cell state transitions.

bioRxiv · Jun 1, 2021 · PreprintBioinformatics