Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control
Lukas‐Adrian Gurzeler, Marion Link, Yvonne Ibig, Isabel Schmidt, Olaf Galuba, Julian Schoenbett, Christelle Gasser-Didierlaurant, Christian N. Parker, Xiaohong Mao, Francis Bitsch, Markus Schirle, Philippe Couttet, Frederic D. Sigoillot, Jana Ziegelmüller, Anne‐Christine Uldry, , Jürgen Reinhardt
The paper introduces two novel readthrough promoters that induce eRF1 degradation, leading to PTC suppression and revealing a new ribosome quality control mechanism.
Cell Reports · Aug 30, 2023Peer-reviewedMolecular Biology