RiboDFM: Robust RNA sequence design using backbone-conditioned discrete flow matching
Xiaocheng Liu, Xiaoyu An, Zhenling Peng, Wenkai Wang, Jianyi Yang
RiboDFM designs RNA sequences that fold into target 3D structures using a backbone-conditioned discrete flow-matching framework, achieving high sequence recovery and tertiary-structure consistency.
bioRxiv · Oct 23, 2026 · PreprintBioinformatics