SpaCir-VDJ: a broadly compatible circularization strategy for spatial immune repertoire profiling
Zheyu Hu, Danni Guo, Xiuyuan Wang, Zhaoxuan Zhang, Zizhao Gao, X F Li, Maiyi Zhong, Xie Wang, Wei Wang, Zi Wang, Xiao Liu
SpaCir-VDJ enables spatial immune repertoire profiling by integrating spatial barcodes and V(D)J sequences into circular templates, revealing clonal organization and somatic hypermutation patterns in human tissues and gastric cancer.
bioRxiv · Apr 29, 2026 · PreprintImmunology