TopoFlow: Evolutionarily Conditioned Flow Matching for Protein Conformational Ensemble Generation
Xinguang Yang, Xinyue cui, Xuhui Li, Dongliang Hou, Suhui Wang, Tengyu Xie, Guijun Zhang
TopoFlow generates protein conformational ensembles using evolutionary and structural information, improving benchmark metrics and aligning with experimental data.
bioRxiv · Sep 24, 2026 · PreprintBioinformatics