Deep learning-guided design of hydrolases for crystalline PET depolymerization
Banghao Wu, Mingchen Li, J C Zhang, Li J, Xuling Wang, Bozitao Zhong, J S Liu, Yunjie Liu, Tan Yang, Tan Yang, Wei Dong Qi, Pan Tan, Weishu Zhao, Lirong Zheng, Liang Hong
This paper designs an engineered PET hydrolase, VenusPETase, using deep learning to enhance PET depolymerization efficiency and thermostability, achieving high TPA yields and complete degradation of commercial PET.
bioRxiv · Jun 5, 2026 · PreprintBiochemistry