Cancer BiologybioRxivPreprint
Fibronectin, DHPS and SLC3A2 Signaling Cooperate to Control Tumor Spheroid Growth, Subcellular eIF5A1/2 Distribution and CDK4/6 Inhibitor Resistance
C. Geller, J. Maddela, R. Tuplano…·J. A. Kelber
This study identifies a mechanism by which fibronectin modulates eIF5A1/2 localization and cell cycle progression in TNBC, revealing that targeting DHPS/SLC3A2 improves CDK4/6 inhibitor efficacy.
DOI 10.1101/2023.04.13.536765