Fibronectin, DHPS and SLC3A2 Signaling Cooperate to Control Tumor Spheroid Growth, Subcellular eIF5A1/2 Distribution and CDK4/6 Inhibitor Resistance
C. Geller, J. Maddela, R. Tuplano, F. Runa, Y. Adamian, R. Guth, G. O. Soto, L. Tomaneng, J. Cantor, J. A. Kelber
This study identifies a mechanism by which fibronectin modulates eIF5A1/2 localization and cell cycle progression in TNBC, revealing that targeting DHPS/SLC3A2 improves CDK4/6 inhibitor efficacy.
bioRxiv · Apr 13, 2023 · PreprintCancer Biology