Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supra-Lethal Dose of Soman in Cynomolgus Monkeys Post-treated with Conventional Antidotes
M. Lane, D. Carter, J. D. Pescrille, Y. Aracava, W. P. Fawcett, G. W. Basinger, E. F. R. Pereira, E. X. Albuquerque
This study shows oral galantamine pretreatment reduces acute toxicity of a high dose of soman in monkeys treated with standard antidotes, improving survival and reducing neuronal damage.
bioRxiv · Feb 3, 2020Pharmacology & Toxicology