The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm
L. Wehrli, I. Galdadas, L. Voirol, M. Smiesko, Y. Cambet, V. Jaquet, S. Guerrier, F. Gervasio, S. Nef, R. Rahban
This study screens 1,280 drugs on human sperm Ca2+ channels, finding 53% of steroids increase [Ca2+]i and inhibit progesterone-induced Ca2+ influx, with some activating CatSper and affecting sperm motility and acrosomal exocytosis.
bioRxiv · May 10, 2023Cell Biology