HighFold-Lasso: Topology-Guided Prediction of Lasso Peptide Structures Using AlphaFold3
Sen Cao, Chengyun Zhang, Hanjie Yang, Yutong Ge, Hongli Hou, Zhu Ning, Yaling Wu, Jisong Mo, Juan Guo, Chongyang Li, JINGJING GUO, Hongliang Duan
HighFold-Lasso predicts lasso peptide structures using topology-guided methods, achieving perfect topology success and low RMSD on a test set of 52 structures.
bioRxiv · Oct 16, 2026 · PreprintBioinformatics