Fibroblast-IL-7 feedback drives PDPN+ monocytes to restrain CD4+ T cell responses
Yan Fu, Christophe Toussaint, Ina Sauerland, Elisabeth Reiß, Lars Philipsen, Patricia Gintschel, Laura Knop, Andreas Dominik Braun, Bastian Kruse, Leon-Alexander Dewitz, Jonas Amore, Vladyslava Dovhan, Sönke Weinert, Nouria Jantz-Naeem, Iris Baars, , Andreas J. Müller
The paper identifies a fibroblast-IL-7 feedback loop that promotes immunosuppressive monocyte-derived cells, which restrain CD4+ T cell responses during infection.
bioRxiv · Apr 2, 2026 · PreprintImmunology