Seesaw configuration of the ODC-OAZ1-AZIN1 axis governs sensitivity to polyamine-targeting inhibitors of breast cancer cells
Yuan Gao, Jinzhu Li, Yutong Jiao, Yan Ji, Mengxi He, Chuang Shi, Sen Liu
This study identifies a seesaw configuration of the ODC-OAZ1-AZIN1 axis that determines breast cancer cell sensitivity to polyamine-targeting inhibitors, offering a framework for personalized therapy.
bioRxiv · Nov 3, 2026 · PreprintCancer Biology