SeverYX: An ensemble framework for robust variant severity classification
Evyatar Mor, Eldar Dedic, Yaron Mazor, Suzanne Drury, Hagar Mor-Shaked, Lina Zelinger
SeverYX is an ensemble framework that classifies genetic variants into severity tiers, achieving high concordance with ClinVar and improving predictive accuracy through threshold optimization and additional predictors.
bioRxiv · Nov 4, 2026 · PreprintGenetics