CD33 and Clusterin Interact Biophysically and Genetically to Modulate Alzheimer Risk
Roger B. Dodd, Masahiro Enomoto, Ye Zhou, Kanayo Satoh, Yalun Zhang, Fusheng Chen, Beatrice Acheson, Deniz Ghaffari, Elizabeth Sayn-Wittgenstein, Jamie J. Manning, George V. Dukas, Ronak Patel, Alondra Schweizer Burguete, Mason J. Kralovec, Mamunur Rashid, , Peter St George‐Hyslop
This study shows how non-coding variants in CD33 affect Alzheimer's risk by altering CD33M dimerization and interactions with clusterin and Aβ, impacting microglial function.
DOAJ (DOAJ: Directory of Open Access Journals) · Jul 1, 2026Peer-reviewedNeuroscience