Yi Qiao

Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotype and phenotype in chronic lymphocytic leukemia

This study uses long-read scRNA-seq to analyze cancer subclone-specific mutations and transcriptomic differences in CLL patients with BTKC481S mutations.

A precision oncology-focused deep learning framework for personalized selection of cancer therapy

This paper introduces ScreenDL, a deep learning model that predicts effective cancer therapies using tumor omic and drug screening data, outperforming existing methods in preclinical trials.

Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes

This study shows SCLC cells exist in a continuum of plastic states rather than discrete subtypes, with gene expression patterns linked to cancer hallmarks and potential therapeutic targets.

gene.iobio: an interactive web tool for versatile, clinically-driven variant interrogation and prioritization

gene.iobio is a web tool that enables clinicians and researchers to interactively analyze and prioritize genomic variants for clinical diagnosis and patient care.

quickBAM: a parallelized BAM file access API for high throughput sequence analysis informatics

quickBAM accelerates BAM file access by utilizing parallel storage hardware, significantly reducing analysis time for genomic data processing.

Mobile Element Insertions and Associated Structural Variants in Longitudinal Breast Cancer Samples

The paper analyzes mobile element insertions and structural variants in longitudinal breast cancer samples to assess their timing and impact on tumor progression.

genepanel.iobio - an easy to use web tool for generating disease- and phenotype-associated gene lists

genepanel.iobio generates disease- and phenotype-associated gene lists by integrating multiple gene:disease resources, improving diagnostic variant prioritization in undiagnosed cases.