Author

Yi Shen

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aaron N. HataiD· 1 shared Anahita Nimbalkar· 1 shared Bang-Zhen PaniD· 1 shared Changning LiuiD· 1 shared Chendi LiiD· 1 shared Christopher J. GraseriD· 1 shared Haiting ZhaoiD· 1 shared HaiXiang Ma· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

Aaron N. HataORCID

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3 papers

Recent·Most cited

Chromosome-scale genome of the woody oilseed crop sacha inchi elucidates the molecular basis of alpha-linolenic acid biosynthesis and triacylglycerol accumulation in seeds

Bang-Zhen Pan, Xuan Zhang, Xiaodi Hu, Qiantang Fu, Mao-Sheng Chen, Yan-Bin Tao, Long-Jian Niu, Huiying He, Yi Shen, Zhukuan Cheng, Tiange Lang, Changning Liu, Zeng‐Fu Xu

This study presents a chromosome-scale genome of sacha inchi, revealing mechanisms of ALA biosynthesis and TAG accumulation through transcriptome analysis and gene expression patterns.

Industrial Crops and Products · Aug 24, 2026Peer-reviewedGenomics

Targeted therapy-induced chromosomal instability dictates mitotic dependency on Aurora Kinase A

Chendi Li, Varuna Nangia, Melissa D Vieira, Anahita Nimbalkar, Christopher J. Graser, Jeremy B. Chang, Mohammad U. Syed, Yi Shen, Radhika Koranne, Lee Zou, Xueqian Gong, Sabrina L. Spencer, Aaron N. Hata

This study shows that KRASG12C inhibition induces chromosomal instability (CIN) in NSCLC cells, which synergizes with Aurora Kinase A inhibition to enhance therapeutic efficacy.

bioRxiv · Jan 23, 2026 · PreprintCancer Biology

Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest

Yue Liang Shen, HaiXiang Ma, Han Lu, Haiting Zhao, Jianliang Sun, Yuan Cheng, Yi Shen, Yu Dong Zhou, HongHai Zhang

The paper investigates how norepinephrine synthesis and neurotransmission deficits contribute to seizure-induced respiratory arrest and identifies NE-1R as a potential therapeutic target for SUDEP prevention.

Biomedicine & Pharmacotherapy · Nov 21, 2020Peer-reviewedNeuroscience