HDGF supports anti-apoptosis and pro-fibrosis in pancreatic stellate cells of pancreatic cancer
Yi-Ting Chen, Tso-Wen Wang, Tsung-Hao Chang, Teng-Po Hsu, Jhih-Ying Chi, Yu-Wei Hsiao, Chien-Feng Li, Ju-Ming Wang
This study identifies the TGF-β1-activated CEBPD/HIF-1/HDGF axis in pancreatic stellate cells, showing HDGF promotes anti-apoptosis and pro-fibrosis, contributing to pancreatic cancer progression.
bioRxiv · Nov 6, 2018 · PreprintCancer Biology