ctDNA Release Heterogeneity in Luminal Breast Cancer Revealed by Single-Cell Multi-Omics Spatial Analysis
Hengyi Xu, Pengming Pu, Binliang Liu, Yuyan Gong, Jiang Wu, Changyuan Guo, Heng Cao, Ziqi Jia, Yuchen Liu, Yansong Huang, Dongxu Ma, Jiayi Li, Zizhao Guo, Tongxuan Shang, Lin Cong, , Jiaqi Liu
The paper identifies cellular and spatial determinants of ctDNA release in HR+/HER2- breast cancer using single-cell multi-omics spatial analysis, linking tumor states, mutations, and immune interactions to ctDNA release patterns.
bioRxiv · Sep 28, 2026 · PreprintCancer Biology