Yu Fu

Programmable sequence-resolved in situ profiling of glycoRNA-protein interactomes by GlycoRNA-Map

This paper introduces GlycoRNA-Map, a method to profile glycoRNA-protein interactomes, revealing that glycoRNA sequences and cellular context shape their protein environments.

Fitness advantage of sequential metabolic strategies emerges from community interactions in strongly fluctuating environments

The paper compares fitness of microbial metabolic strategies in fluctuating environments, finding sequential utilizers gain an advantage in diverse communities.

A Haplotype-resolved Telomere-to-Telomere Pig Genome

This paper presents a haplotype-resolved telomere-to-telomere pig genome, revealing new protein-coding loci and enabling xenograft cell state analysis and interspecies chimerism compatibility scoring.

A Phospho-Switch for Cell Fate Control

The paper identifies a phospho-switch in SALL4 that controls cell fate by modulating BAF complex interaction in response to BMP4-DUSP9 signaling, causing developmental defects when disrupted.

Genetic Analysis of Flagellar-Mediated Surface Sensing by Pseudomonas aeruginosa PA14

This study identifies key bacterial proteins involved in flagellar-mediated surface sensing in P. aeruginosa, showing their role in regulating c-di-GMP levels and biofilm formation.

Visualization and review of reads alignment on the graphical pan-genome with VAG

The paper introduces VAG, a tool for visualizing and analyzing read alignments on graph pangenomes, and demonstrates its application in identifying genetic variations in rice and other species.

The arms race in noncoding regions of transposable element: the evolution of anti-silencing and RNAi

The paper shows that RNAi targets noncoding regions of VANDAL TEs, while VANC proteins evolved to escape this silencing, suggesting a co-evolutionary arms race between TEs and host defense mechanisms.

Repurposing antihypertensive, lipid-lowering and antidiabetic drugs for lacunar stroke

This study uses Mendelian randomization to assess the causal effects of risk factors and drug targets on lacunar stroke, identifying potential drug repurposing opportunities.

Aging increases lateral but not local inhibition of orientation processing in primary visual cortex

This study shows aging increases lateral inhibition but not local inhibition in primary visual cortex using behavioral and computational methods.