A lifespan-scale single-cell atlas defines an early-childhood immunometabolic transition linked to age-referenced immune states
Jiayi Zheng, Yu Shi, Yichen Sun, Yalin Wang, Ruoxin Li, Peng Wang, ShiRu Chang, Lanxin Pan, Huiling Tan, Tong Yue, Kun Qu, Xueying Zheng, Chuang Guo, Jianping Weng
The paper constructs a lifespan single-cell atlas of immune cells, identifies an early-childhood immunometabolic transition around age 6, and develops an age-referenced framework for immune-state analysis.
bioRxiv · Sep 18, 2026 · PreprintImmunology