L-Lactate reprograms tumor-associated macrophages to drive pancreatic cancer progression via BCL3 lactylation
Peixuan Ji, Jia-Hao Zheng, Xue-Shiyu Ma, Feng Yu, Ya-Wen Lu, Qi Wo, Kan Xu, Minwei Yang, Jian‐Yu Yang, Wei Liu, Xueliang Fu, Yan-Miao Huo, Wen-Yi Gu, Yu-Jun HAO, Shu‐Heng Jiang, , Yong-Wei Sun
This study shows that L-lactate reprograms tumor-associated macrophages via BCL3 lactylation, promoting pancreatic cancer progression by suppressing inflammation and supporting tumor networks.
bioRxiv · Mar 10, 2026 · PreprintCancer Biology