Mechanism of GPR84 allosteric modulation at a helix 8-proximate site
Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Jingkai Zhou, Fabian Gossen, Pinqi Wang, Zobaer Al Mahmud, Yueming Li, Andhika Bintang Mahardhika, Christa Elisabeth Müller, Mingye Feng, Angela J. Russell, Irina G. Tikhonova, Graeme Milligan, Cheng Zhang
This paper identifies a helix 8-proximate allosteric site in GPR84 and shows how it enables Gi-biased signalling through structural and dynamic mechanisms.
Science Advances · Sep 23, 2026Peer-reviewedBiochemistry