Oxidized EGCG redirects α-synuclein aggregation through shear-selected interactions
Cho Ming Yuen, Reiji Yamaguchi, Keita Uchida, Yosuke Shimada, Yusuke Shuto, Shunta Sakamoto, Daichi Morimoto, Hajime Ono, Masatomo So, Ayako Furukawa, Kenji Sugase
This study shows that oxidized EGCG, not unoxidized EGCG, binds α-synuclein, inhibits fibrillation, and remodels fibrils, with shear flow affecting these interactions.
bioRxiv · Oct 30, 2026 · PreprintBiochemistry