Author

Yuval Klein

Technion – Israel Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Neta MilmaniD· 2 shared Shai S. Shen-OrriD· 2 shared Timothy J Few-CooperiD· 2 shared Abhishek SinhaiD· 1 shared Amir Grau· 1 shared Ayelet Alpert· 1 shared Bettia E. CelestiniD· 1 shared Dana Harshuk-Shabso· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

Neta MilmanORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Immune Aging is an Independent Risk Factor for Cardiovascular Disease

Erik Feldman, Everton J. Santana, Bettia E. Celestin, Nadav Golden, Shadi P. Bagherzadeh, Sofia Maysel-Auslender, Kavita Mathi, Sarah Short, Megan Caroll, Shannon S. Sullivan, Martin Lukačišin, Xuhuai Ji, Yuval Klein, Oren Caspi, Patricia Kim Phuong Nguyen, , Shai S. Shen-Orr

The paper introduces IMM-AGE, a metric of immune-aging, and shows it independently predicts cardiovascular disease risk across multiple cohorts.

bioRxiv · Sep 6, 2026 · PreprintImmunology

A systems approach to B-cell development identifies BDNF as a regulator of human B lymphopoiesis

Neta Nevo, Yuval Klein, Ayelet Alpert, Amir Grau, Doron Melamed, Timothy J Few-Cooper, Neta Milman, Shai S. Shen-Orr

This study identifies BDNF as a regulator of human B lymphopoiesis using a systems biology approach integrating single-cell transcriptomics and intercellular communication mapping.

bioRxiv · Aug 29, 2025 · PreprintSystems Biology

Redox-driven control of Yuh1/UCHL3 impacts mitochondrial health via NEDD8/Rub1 pathway

Soha Issa, Yuval Klein, Eden Berda, Shahaf Saad, Dana Harshuk-Shabso, Abhishek Sinha, Yehonatan Sharaby, Moran Benhar, Elah Pick

The paper investigates how redox changes affect Yuh1/UCHL3 activity, revealing a thiol-based redox switch that modulates NEDD8/Rub1 processing and impacts mitochondrial health.

Redox Biology · May 8, 2025Peer-reviewedCell Biology