Author

Zach Nussbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Approach:diffusion model· 1

Frequent Co-Authors

Aaron WenteleriD· 1 shared Albi CelajiD· 1 shared Alice Jiexin Gao· 1 shared Alston LoiD· 1 shared Amit G. DeshwariD· 1 shared Amrudha Mohan· 1 shared Aniketh Janardhan ReddyiD· 1 shared Arathi Shanavas· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperSynthetic Biology

Aaron WentelerORCID

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Author profile →

2 papers

Recent·Most cited

DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements

Lucas F. daSilva, Simon Senan, Zain Munir Patel, Aniketh Janardhan Reddy, Sameer Gabbita, Zach Nussbaum, Cesar Miguel Valdez Cordova, Aaron Wenteler, Noah Weber, Tin M. Tunjic, Talha Ahmad Khan, Zelun Li, Cameron Smith, Matei Bejan, Lithin Karmel Louis, , Luca Pinello

DNA-Diffusion uses diffusion models to generate cell type-specific regulatory DNA sequences that modulate chromatin accessibility and gene expression.

bioRxiv · Feb 1, 2024 · PreprintSynthetic Biology

An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics

Albi Celaj, Alice Jiexin Gao, Tammy Lau, Erle M. Holgersen, Alston Lo, Varun Lodaya, Christopher B. Cole, Robert Edward Denroche, Carl Spickett, Omar Wagih, Pedro O. Pinheiro, Parth Vora, Pedrum Mohammadi‐Shemirani, Steve Chan, Zach Nussbaum, , Brendan J. Frey

The paper introduces BigRNA, an RNA foundation model that predicts RNA biology from DNA sequence and identifies therapeutic effects of SBOs on gene expression and splicing.

bioRxiv · Sep 20, 2023 · PreprintBioinformatics