Author

Jason Hsiao

University of California San DiegoORCID 0000-0002-1663-9365Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:benchmark study· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

Dyann F. WirthiD· 2 shared Elizabeth A. WinzeleriD· 2 shared Priyan Kapoor· 2 shared Abhiram ChalamalasettyiD· 1 shared Adrián JinichiD· 1 shared Aidan Dunleavy· 1 shared Aidan NeheriD· 1 shared Aixin Li· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

Dyann F. WirthORCID

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3 papers

Recent·Most cited

De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication

Jason Hsiao, Melina Shamshoum, Abhiram Chalamalasetty, Jordan R. Barrett, Ricardo Almada‐Monter, Elizabeth Tabornal, Emily Wilks, Yi-Zong Lee, Nathan Beutler, Amanda Richard Lukens, Priyan Kapoor, Daisy Chen, Justice Ndihokubwayo, Barnabas G. Williams, Kirsty McHugh, , Adrián Jinich

This paper designs de novo minibinders that inhibit blood-stage malaria replication with nanomolar potency by targeting the RH5-basigin interaction.

bioRxiv · Sep 29, 2026 · PreprintMicrobiology

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors

Fu-Hsuan Ko, Amanda K. Lukens, Mariana Laureano de Souza, Alex Foy, Jason Hsiao, Tolla Ndiaye, John Okombo, Tomas Yeo, Heekuk Park, Anne‐Catrin Uhlemann, Nonlawat Boonyalai, Krittikorn Kümpornsin, Gareth Girling, Charisse Flerida A. Pasaje, Luiz Claudio Godoy, , Elizabeth A. Winzeler

This study identifies divergent resistance mechanisms in Plasmodium HSP90 inhibitors despite shared binding sites, showing that enhanced binding can paradoxically correlate with resistance.

Cell Reports · Jul 1, 2026Peer-reviewedMicrobiology

Putting computational models of immunity to the test - an invited challenge to predict B. pertussis vaccination outcomes

Pramod S. Shinde, Lisa Willemsen, Michael Anderson, Minori Aoki, Saonli Basu, Julie G. Burel, Peng Cheng, Souradipto Ghosh Dastidar, Aidan Dunleavy, Tal Einav, Jamie Forschmiedt, Slim Fourati, Javier Garcia, William Gibson, Jason A Greenbaum, , Bjoern Peters

The paper benchmarks 49 algorithms for predicting B. pertussis vaccination outcomes, finding that purpose-built models outperform literature-based ones due to better handling of nonlinearities and data preprocessing.

PLoS Computational Biology · Mar 31, 2025Peer-reviewedImmunology