Author

Aman Shihora

University of WashingtonORCID 0000-0002-4635-3480Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A.Felicia AdebanjoiD· 1 shared Abbye E. McEweniD· 1 shared Alan F. RubiniD· 1 shared Alice H. BergeriD· 1 shared Allyssa J. VandiiD· 1 shared Daniel L. HolmesiD· 1 shared Douglas M. FowleriD· 1 shared Dustin J. MalyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenomics

A.Felicia AdebanjoORCID

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1 paper

Recent·Most cited

Pathway-scale variant effect mapping reveals the importance of cell context

Jessica J. Simon, Sriram Pendyala, A.Felicia Adebanjo, Daniel L. Holmes, Madeline Walsh, Allyssa J. Vandi, Ziyu R. Wang, Melinda K. Wheelock, Jordan L. Opsahl, Aman Shihora, Abbye E. McEwen, Nahum T. Smith, Siobhan O’Brien, Melissa Hopkins, Alan F. Rubin, , Douglas M. Fowler

The paper measures variant effects across the MAPK pathway in human cells, revealing how cell context influences variant function and identifying 14,412 previously unknown dominant negative variants.

bioRxiv · Oct 11, 2026 · PreprintGenomics