Author

Lindsey G. Siegfried

University of CincinnatiORCID 0000-0002-6561-4113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Caroline DodsoniD· 2 shared Jie WangiD· 2 shared Linli ZhouiD· 2 shared Sarah E. MillariD· 2 shared Thomas AndliD· 2 shared Yuhang ZhangiD· 2 shared Anthony J. GriswoldiD· 1 shared Bruna da Silva SoleyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersDevelopmental Biology

Caroline DodsonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BMP6 coordinates dermal papilla and epithelial cell states for hair follicle engineering and regeneration

Lindsey G. Siegfried, Linli Zhou, Jie Wang, Jennifer M. Hahn, Caroline Dodson, Yeon Sook Choi, Jodie L. Babitt, Dorothy M. Supp, Sarah E. Millar, Thomas Andl, Yuhang Zhang

This study identifies BMP6 as a regulator that maintains dermal papilla function and promotes epithelial differentiation in hair follicle engineering.

bioRxiv · Oct 2, 2026 · PreprintDevelopmental Biology

Nuclear force transmission drives cancer-associated fibroblast activation under BRAF inhibition

Jie Wang, Bruna da Silva Soley, Yao Xiao, Lindsey G. Siegfried, Linli Zhou, Mingang Xu, Sarah E. Millar, Thomas Andl, Yuhang Zhang

This study identifies a mechanotransduction pathway in cancer-associated fibroblasts (CAFs) where BRAF inhibition and matrix stiffness converge to drive nuclear remodeling and CAF activation through the ROCK-cytoskeleton-nucleus axis.

bioRxiv · Jul 19, 2025 · PreprintCancer Biology

A human ex vivo model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic response

Caroline Dodson, Sophie M. Bilik, Gabrielle DiBartolomeo, Hannah Pachalis, Lindsey G. Siegfried, Jordan A.K. Johnson, Seth Ray Thaller, Irena Pastar, Marjana Tomic‐Canic, Anthony J. Griswold, Rivka C. Stone

This study develops a human ex vivo skin model that recapitulates radiation-induced DNA damage and fibrotic responses, identifying p53-driven pathways and potential therapeutic targets.

bioRxiv · Jun 4, 2025 · PreprintGenomics