Author

Michelle S. Hirsch

Brigham and Women's HospitalORCID 0000-0002-8767-8564Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adam S. KibeliD· 2 shared Eliezer M. Van AlleniD· 2 shared Filipe L.F. CarvalhoiD· 2 shared Jihye ParkiD· 2 shared Adam Scott FeldmaniD· 1 shared Amanda GarzaiD· 1 shared Breanna M. TitcheniD· 1 shared Brendan Michael ReardoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Adam S. KibelORCID

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2 papers

Recent·Most cited

Tumor-myeloid crosstalk drives therapy resistance in localized bladder cancer

Filipe L.F. Carvalho, Ji‐Hyun Lee, Nikolaos Kalavros, Yuzhen Zhou, Daniel E. Michaud, Isabella Stelter, Hiba Siddiqui, Konrad Stawiski, Ramya Ravindranathan, Julia Perera, Shuoshuo Wang, Breanna M. Titchen, Amanda Garza, Kevin Bi, Jihye Park, , Eliezer M. Van Allen

This study identifies tumor-myeloid crosstalk as a driver of cisplatin resistance in bladder cancer and proposes PARP14 inhibition as a therapeutic strategy.

Cell Press Blue · Aug 20, 2026Peer-reviewedCancer Biology

Genomic analysis of BCG unresponsive non-muscle-invasive bladder cancer identifies drivers of sensitivity to intravesical Gemcitabine/Docetaxel

Kendrick H. Yim, Matías Vergara, Jihyun Lee, Brendan Michael Reardon, J Park, Kevin Richard Melnick, Timothy N. Clinton, Matthew Mossanen, Graeme S. Steele, Jessica Bolduc, Michelle S. Hirsch, Natalie M. Rizzo, Chin‐Lee Wu, Matthew F. Wszolek, Keyan Salari, , Filipe L.F. Carvalho

The paper identifies genomic features associated with response or resistance to Gem/Doce in BCG-unresponsive NMIBC using whole-exome sequencing and phylogenetic analysis.

bioRxiv · May 18, 2026 · PreprintGenomics