Pattern Of Some Inflammatory Mediators Among Adult Patients With Bronchial Asthma On Corticosteroids Attending Aminu Kano Teaching Hospital, Kano, Nigeria

Abstract

BackgroundBronchial asthma in adults is typified by lingering allergic inflammation associated with elevation in the levels of certain acute phase reactants and indicators of mast cell activation. This study investigated the effect of corticosteroid treatment on the levels of C reactive protein (CRP), serum baseline tryptase (sBT), erythrocyte sedimentation rate (ESR) and granulocyte monocyte colony stimulating factor (GM-CSF) among asthmatics. MethodForty five adult patients with bronchial asthma on treatment with inhaled corticosteroids were enrolled. Forty five blood donors were used as control. Serum levels of CRP, sBT, ESR and GM-CSF were measured using sandwich ELISA. ResultThe GM-CSF, CRP, ESR and sBT were significantly elevated among asthmatics on treatment compared to normal healthy control. Significant difference in the level of GM-CSF, ESR and CRP was observed between asthmatics with mild and moderate disease severity. ConclusionTreatment with inhaled corticosteroids doesnt restore the levels of GM-CSF, CRP, sBT and ESR to normalcy among asthmatics.