A. Ibrahim

Insights Into Parkinsons Disease Genetics in African Populations: Expanded GWAS Identifies Ancestry-Specific and Cross-Population Risk Loci

This paper conducts a GWAS in African and African admixed populations, identifying ancestry-specific and cross-population risk loci for Parkinson's disease.

Efficacy of an oral lipid nanocrystal (LNC) formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis

This study compares the efficacy of oral MAT2203 to intravenous LAMB in a neutropenic mouse model of mucormycosis, finding MAT2203 as effective in survival and fungal burden reduction.

The effects of protein supplementation, fumagillin treatment, and colony management on the productivity and long-term survival of honey bee (Apis mellifera) colonies in Canada

This study evaluates the effects of protein supplements and fumagillin on honey bee colony productivity and survival across different Canadian regions, finding context-dependent benefits.

Nuclear cytoglobin associates with HMGB2 and regulates DNA damage and genome-wide transcriptional output in the vasculature

This study identifies nuclear cytoglobin's role in regulating DNA damage and transcriptional output in vascular smooth muscle cells through its interaction with HMGB2.

Insights from a survey of mentorship experiences by graduate and postdoctoral researchers

This study surveys graduate and postdoctoral researchers to assess mentorship quality, finding dissatisfaction in 25-45% of respondents and identifying common issues and strategies to improve mentorship.

Anticancer efficacy of KRASG12C inhibitors is potentiated by PAK4 inhibitor KPT9274 in preclinical models of KRASG12C mutant pancreatic and lung cancers

This study shows that combining KRASG12C inhibitors with PAK4 inhibitor KPT9274 enhances antitumor activity and survival in preclinical models of KRASG12C mutant pancreatic and lung cancers.

The faculty-to-faculty mentorship experience: a survey on challenges and recommendations for improvements

This study surveys early- and mid-career faculty to assess mentorship experiences, identifying challenges and recommending improvements for faculty mentorship programs.

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.

Pattern Of Some Inflammatory Mediators Among Adult Patients With Bronchial Asthma On Corticosteroids Attending Aminu Kano Teaching Hospital, Kano, Nigeria

This study examines the effect of inhaled corticosteroids on inflammatory mediators in adult asthma patients, finding elevated levels of GM-CSF, CRP, ESR, and sBT compared to controls, with differences by disease severity.

The conditional defector strategies can violate the most crucial supporting mechanisms of cooperation.

This paper uses agent-based models to show conditional defectors can undermine key cooperation mechanisms like kin selection and punishment, suggesting cooperation is harder to maintain than previously thought.

Niclosamide loaded Eudragit EPO nanoparticles show enhanced Candida biofilm penetration, trigger biofilm detachment and protect from mucosal candidiasis

This study identifies Niclosamide as a drug that disrupts Candida biofilms and develops nanoparticles to enhance its efficacy against drug-resistant strains.

Fitm2 is required for ER homeostasis and normal function of murine liver

This study shows that Fitm2 is essential for ER homeostasis and liver function in mice, with loss of Fitm2 causing ER stress and liver injury.

I-M-150847, a novel GLP-1 and GIP receptor dual agonist, improves glycemic control and reduces obesity in the rodent model of type 2 diabetes and obesity.

Identification of Serum Bridging Molecules that Mediate Human Endothelial Cell Invasion by Candida species

This paper identifies serum proteins that mediate endothelial cell invasion by non-C. albicans Candida species through bridging molecule-mediated endocytosis.

Adapted protocol for Saccharibacteria co-cultivation: two new members join the club of Candidate Phyla radiation

This paper develops a co-cultivation protocol for Saccharibacteria, successfully isolating two new species and providing tools for their quantification and study.

Small and equipped: the rich repertoire of antibiotic resistance genes in Candidate Phyla Radiation genomes

The paper analyzes 4,062 CPR genomes to discover a rich repertoire of antibiotic resistance genes, finding 30,545 hits across 13 CPR phyla, with most linked to common antibiotic classes.

Baseline epidemiology and associated dog ecology study towards stepwise elimination of rabies in Kwara state, Nigeria

This study assesses dog population dynamics and vaccination status in Kwara State, Nigeria, identifying factors influencing vaccination coverage and dog bite prevalence.

A mixed model approach for estimating drivers of microbiota community composition and differential taxonomic abundance

This paper introduces a GLMM-based approach to analyze microbiota community composition and differential taxonomic abundance in meta-barcoding data, showing age group better explains gut microbiota variation than season in Soay Sheep.

An evolutionarily diverged mitochondrial protein controls biofilm growth and virulence in Candida albicans

This study identifies orf19.2500 as a mitochondrial protein essential for biofilm growth, virulence, and drug resistance in Candida albicans, with unique evolutionary inserts.

Honey bee queen production: Canadian costing case study and profitability analysis

This study analyzes the economic feasibility of Canadian honey bee queen production, showing it can be profitable for small to medium operations with cost savings from reusing materials and economies of scale.

Comparison of algorithms for the detection of enteroviruses in stool specimens from children diagnosed with Acute Flaccid Paralysis

This study compares cell culture-dependent and independent methods for detecting enteroviruses in stool samples from children with Acute Flaccid Paralysis, finding both methods bias diversity perception.