bioRxivMicrobiologyPreprint
Implication of HisF from Acinetobacter baumannii in persistence during a pneumonia infection
M. Martinez-Guitian, J. C. Vazquez-Ucha, L. Alvarez-Fraga, K. Conde-Perez, J. A. Vallejo, G. Bou, M. Poza, A. Beceiro
Abstract
The hisF gene from A. baumannii ATCC 17978 was found over-expressed during a murine pneumonia infection. A mutant strain lacking hisF showed its involvement in virulence during mice pneumonia as well as in host inflammatory response, where the product of HisF may act as negative regulator in the production of pro-inflammatory cytokines. This work evaluates the role of HisF in the A. baumannii pathogenesis and suggests its potential as a new target for antimicrobial therapies.
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