Lytic/Lysogenic Transition as a Life-History Switch

Abstract

The transition between lytic and lysogenic life cycles is the most important feature of the life history of temperate viruses. To explain this transition, an optimal life-history model is offered based a discrete-time formulation of phage/bacteria population dynamics that features infection of bacteria by Poisson sampling of virions from the environment. The time step is the viral latency period. In this model density-dependent viral absorption onto the bacterial surface produces virus/bacteria coexistence and density-dependence in bacterial growth is not needed. The formula for the transition between lytic and lysogenic phases is termed the "fitness switch". According to the model, the virus switches from lytic to lysogenic when its population grows faster as prophage than as virions produced by lysis of the infected cells, and conversely for the switch from lysogenic to lytic. A prophage that benefits the bacterium it infects automatically incurs lower fitness upon exiting the bacterial genome, resulting in its becoming locked into the bacterial genome in what is termed here as a "prophage lock". The fitness switch qualitatively predicts the ecogeographic rule that environmental enrichment leads to microbialization with a concomitant increase in lysogeny, fluctuating environmental conditions promote virus-mediated horizontal gene transfer, and prophage-containing bacteria can integrate into the microbiome of a eukaryotic host forming a functionally integrated tripartite holobiont. These predictions accord more with the "Piggyback-the-Winner" hypothesis than with the "Kill-the-Winner" hypothesis in virus ecology.