G. Li

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

Scalable Generation of Clinical-Grade Universal Human cDC1s Enables Potent Antitumor Immunotherapy

This paper develops a scalable method to generate clinical-grade cDC1s from umbilical cord blood, showing improved antitumor efficacy in mouse models and recapitulating DC differentiation.

The Neuromusculoskeletal Modeling Pipeline: MATLAB-based Model Personalization and Treatment Optimization Functionality for OpenSim

MATLAB toolsets add joint, muscle, synergy, and foot-contact personalization and optimal-control treatment design to OpenSim; one post-stroke case predicted 60% faster walking at equal metabolic cost.

Molecular Evidence of Internal Carbon-Driven Partial Denitrification Annamox (PdNA) in a mainstream Pilot A-B System Coupled with Side-stream EBPR treating municipal wastewater

This study demonstrates that a pilot-scale A-B-S2EBPR system achieves nitrite accumulation and anammox for nitrogen removal in wastewater treatment by utilizing internal carbon sources.

In vivo quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

An extinct clade sister to Eumetazoa: On the phylogeny of the Cambrian chancelloriids

This study describes new fossils of chancelloriids, revealing their unique body plan and suggesting they are a basal clade sister to eumetazoans.

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

Unveiling the PHR-centered regulatory network orchestrating the phosphate starvation signaling in Chinese fir (Cunninghamia lanceolata)

This study identifies ClPHRs as key regulators of phosphate starvation signaling in Chinese fir, revealing evolutionary differences in the SPX-PHR module compared to model plants.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

Determinants of de novo mutations in extended pedigrees of 43 dog breeds

The paper investigates mutation rates in 43 dog breeds, finding stable rates influenced by parental age and breed-specific differences in mutation accumulation.

Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

MAGNETICALLY STEERED CELL THERAPY FOR REDUCTION OF INTRAOCULAR PRESSURE AS A TREATMENT STRATEGY FOR OPEN-ANGLE GLAUCOMA

A magnetic cell therapy reduced intraocular pressure in a glaucoma mouse model, with hAMSCs showing greater efficacy than iPSC-TM cells.

Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle

This study identifies a reassortment event in wild birds leading to HPAI A(H5N1) infection in cattle and highlights the risk of virus spread through asymptomatic cattle to humans.

An AI-designed adenine base editor

This paper introduces ABE10, the first AI-designed adenine base editor validated experimentally, showing improved efficiency and reduced off-target effects compared to existing ABEs.

Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption

The paper analyzes single-cell transcriptomes of aortic smooth muscle cells in mice to show distinct origins and similar transcriptional changes after TGFβ signaling disruption.

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

Highly Pathogenic Avian Influenza A (H5N1) clade 2.3.4.4b Virus detected in dairy cattle

The paper identifies a new genotype of HPAI H5N1 virus in dairy cattle, showing genetic changes but lacking key mutations for mammalian adaptation.

Genetic and anatomical determinants of olfaction in dogs and wild canids

This study investigates the genetic and anatomical basis of olfaction in dogs and wild canids, finding no evidence of human-directed selection for enhanced olfaction in domestic dogs.

In vivo evaluation of thermally drawn biodegradable optical fibers as brain neural interfaces

This study evaluates biodegradable PDLLA optical fibers as neural interfaces in mice, showing degradation and efficient SW-NIR light transmission with potential for optogenetics and therapy.

The impact of Arctic environments on human cerebral blood flow

This study examines changes in cerebral blood flow in Arctic conditions and finds reduced velocity and increased pulsatility in specific arteries.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

Changes in Walking Function and Neural Control following Pelvic Cancer Surgery with Reconstruction

This study assesses changes in walking function and neural control after pelvic cancer surgery with reconstruction using movement data and neuromusculoskeletal modeling.

Pharmacodynamic evaluation of AUM001/tinodasertib, an oral inhibitor of mitogen-activated protein kinase (MAPK)-interacting protein kinase 1, 2 (MNK1/2) in preclinical models and tissues from a Phase 1 clinical study

This paper evaluates the pharmacodynamic effects of AUM001/tinodasertib in preclinical models and human tissues from a Phase 1 study, showing dose-dependent inhibition of eIF4E phosphorylation in tumors and PBMCs.

Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics

This study uses computational models to show that deformable interendothelial slits in the spleen better predict RBC filtration compared to rigid models, improving understanding of splenic hemodynamics and filtration mechanisms.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

SlWRKY80 recruits SlHDA1 to regulates the tomato fruit ripening and color transformation

This study identifies SlWRKY80's role in tomato fruit ripening and color change by regulating SlSGR1 and SlPSY1 through recruitment of SlHDA1.