bioRxivBioengineering
Driving the scalability of DNA-based information storage systems
K. J. Tomek, K. Volkel, A. Simpson, A. G. Hass, E. W. Indermaur, J. Tuck, A. J. Keung
Abstract
The extreme density of DNA presents a compelling advantage over current storage media; however, in order to reach practical capacities, new approaches for organizing and accessing information are needed. Here we use chemical handles to selectively extract unique files from a complex database of DNA mimicking 5 TB of data and design and implement a nested file address system that increases the theoretical maximum capacity of DNA storage systems by five orders of magnitude. These advancements enable the development and future scaling of DNA-based data storage systems with reasonable modern capacities and file access capabilities.
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