T. R. Shepherd

This paper designs, fabricates, and characterizes 3D RNA-scaffolded wireframe origami structures using different RNA sequences, revealing structural insights and demonstrating the potential for functional RNA scaffolds.

This study uses DNA origami to investigate how antigen organization affects B-cell activation, finding that optimal spacing and valency enhance signaling.

This paper demonstrates a method to enable random access of DNA-encoded files in large-scale archival storage by using silica capsules with barcode labels for efficient file selection.

This paper demonstrates the scalable production of custom-length single-stranded DNA (cssDNA) using engineered miniphage in E. coli, enabling applications in DNA origami and archival data storage.

This paper develops an enzymatic method to synthesize long ssDNA sequences (>15 kb) with controlled nucleotide composition for therapeutic and imaging uses.