Sexual function and dysfunction studies

A KCa 2.2/2.3 Opener Reverses ET-1-induced NLRP3 Activation in Hypertensive Mice Corpora Cavernosa

This study shows that activating KCa 2.2/2.3 channels reverses ET-1-induced NLRP3 activation and erectile dysfunction in hypertensive mice.

In-silico Targeting Phosphodiesterase 5 and In-vivo Evaluation of the Aphrodisiac Effect of Azanza garckeana Fruit

This study evaluates the aphrodisiac effects of Azanza garckeana fruit using computational and in-vivo methods, finding significant improvements in sexual function parameters in rats.

Ex Vivo Testing of Inflatable Penile Prosthesis in Human Cadaveric Penis with Paired in Silico Model offering Surgical and Biomechanical Insights

This paper tests an inflatable penile prosthesis in cadaveric tissue and pairs it with a computational model to study mechanical interactions and guide surgical planning.

Urological benchtop and in silico models validated by human penile tissue inflation tests

This study validates benchtop and finite element models of penile tissue inflation using human tissue tests to improve inflatable penile prosthesis design and surgical outcomes.

Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation

This study shows that SG1002, an H2S prodrug, partially protects against erectile dysfunction caused by long-term androgen deprivation in mice.

Cystathionine γ Lyase Deletion Enhances Corpus Cavernosum Contraction via Thromboxane A2 and Neurogenic Pathways Without Affecting Endothelial Function

Hydrogen sulfide protects erectile function through stimulation of antioxidant defense in the corpus cavernosum

This study shows that hydrogen sulfide improves erectile function and reduces oxidative stress in the corpus cavernosum by enhancing antioxidant defenses.

MALAT1 mediates miR-206/CDC42/PAK1/Paxillin signaling axis to alleviate erectile dysfunction in rats

This study identifies a signaling pathway involving MALAT1, miR-206, CDC42, PAK1, and Paxillin that promotes BM-MSC differentiation into ECs and alleviates erectile dysfunction in rats.

Single cell transcriptome analysis of cavernous tissues reveals the key roles of pericytes in diabetic erectile dysfunction

The paper uses single-cell RNA sequencing to analyze diabetic cavernous tissues, identifying pericyte dysfunction and a novel marker LBH that promotes neurovascular regeneration.

Immediate and Long-Term Effects of Tibial Nerve Stimulation on the Sexual Behavior of Female Rats

This study examines the effects of tibial nerve stimulation on sexual behavior in rats, finding short-term increases in motivation and long-term trends in receptivity when combined with hormone priming.

GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

A GWAS of erectile dysfunction identifies a new locus at 6q16.3, implicating hypothalamic neurobiology and diabetes in its etiology.